What does it mean to get the deepest clean?
- BRUSHING AND FLOSSING disrupt biofilm but DON’T KILL biofilm BACTERIA, allowing it to RECOLONIZE ON DENTAL SURFACES1,2
- LISTERINE® Antiseptic penetrates and kills both
free-floating BIOFILM (planktonic) and biofilm that is still attached to the teeth, gums, or cheeks (sessile) to achieve the deepest clean - LISTERINE® Antiseptic penetrates biofilm deeper to deliver 3X SUPERIOR KILL POWER vs
CREST® PRO—HEALTH™ and COMPARABLE KILL POWER TO PERIDEX™6*
How does LISTERINE® Antiseptic penetrate and kill plaque biofilm?
LISTERINE® Antiseptic attacks bacteria and inhibits
regrowth using a fixed combination of 4 essential oils: eucalyptol, menthol, methyl salicylate, and thymol
- DAMAGES the bacterial cell surface3,4
- INTERFERES with biofilm growth5
- INCREASES the time it takes for bacteria to grow back3
- DECREASES levels of bacterial chemicals that cause inflammation3
*vs CREST® PRO–HEALTH™ Rinse in vitro.
LISTERINE® Antiseptic attacks and kills biofilm bacteria where it lives
Rinsing 30 seconds twice daily with 20 ml of
full-strength LISTERINE® Antiseptic yields greater bacterial kill and greater plaque reduction*
BEFORE
Scanning electron micrograph (SEM) of biofilm not treated with LISTERINE® Antiseptic
AFTER
SEM of biofilm treated with LISTERINE® Antiseptic
CLOSE-UP
SEM of ruptured bacterial cell wall in LISTERINE® Antiseptic-treated biofilm
Images courtesy of Christoph Schaudinn, PhD, University of Southern California School of Dentistry, Center for Biofilms.
How much deeper is the LISTERINE® Antiseptic clean?
Study confirms the powerful biofilm kill of LISTERINE® Antiseptic5
- In this lab model, saliva-derived biofilms were grown on saliva-coated glass slides
- Biofilms were cultured for 65 hours prior to mouthrinse exposure
- Biofilms were stained to enable quantification of the live/dead cells
Powerful biofilm kill without the side effects5-9
- Superior kill vs CPC-based rinses (0.05% to 0.07%) like CREST® PRO–HEALTH™, without the side effect of staining5,10
- Comparable kill vs CHX-containing rinses (0.12%) like PERIDEX™, without the side effects of staining and altered taste11
How does LISTERINE® Antiseptic help your patients achieve an overall healthier mouth?
In a long-term clinical study,
LISTERINE® Antiseptic showed comparable reduction of gingivitis at 6 months vs PERIDEX™12
- In this lab model, saliva-derived biofilms were grown on saliva-coated glass slides
- Biofilms were cultured for 65 hours prior to mouthrinse exposure
- Biofilms were stained to enable quantification of the live/dead cells
Powerful biofilm kill without the side effects5-9
- Superior kill vs CPC-based rinses (0.05% to 0.07%) like CREST® PRO–HEALTH™, without the side effect of staining5,10
*vs Crest Pro-Health Rinse in vitro.
†ADVANCED LISTERINE® (Citrus or ARCTIC MINT®) does not carry the ADA Seal of Acceptance.
- 52% greater plaque reduction at 6 months when added to brushing and flossing13
- 21% greater gingivitis reduction vs brushing and flossing13
- In a separate study, up to 70% greater plaque reduction was demonstrated with LISTERINE® Antiseptic vs brushing alone5
The ADA Council on Scientific Affairs’
Acceptance of LISTERINE® Antiseptic is
based on its finding that the product is effective in helping to prevent or reduce gingivitis and plaque above the gumline, when used as directed.†
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1.Loesche WJ, Svanberg ML, Pape HR. Intraoral transmission of Streptococcus mutans by a dental explorer. J Dent Res. 1979;58(8):1765-1770. 2.Edman DC, Keene HJ, Shklair IL, Hoerman KC. Dental floss for implantation and sampling of Streptococcus mutans from approximal surfaces of human teeth. Arch Oral Biol. 1975;20(2):145-148. 3.Fine DH, Furgang D, Lieb R, et al. Effects of sublethal exposure to an antiseptic mouthrinse on representative plaque bacteria. J Clin Periodontol. 1996;23(5):444-451. 4.Kubert D, Rubin M, Barnett ML, Vincent JW. Antiseptic mouthrinse-induced microbial cell surface alterations. Am J Dent. 1993;6(6):277-279. 5.Data on file, McNEIL-PPC, Inc. 6.Lux R, Pan SD, Castaneda JH, et al. Biocidal activity of antiseptic mouthrinses in saliva-derived biofilm model. Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. Abstract 1339. 7.Pan P, Lux R, Shi W, et al. Evaluation of plaque biofilm kill activity of representative global mouthrinses. Presented at: American Association for Dental Research Annual Meeting; April 2-5, 2008; Dallas, TX. Abstract 0031. 8.Araujo MWB, Pan P, Lux R, Shi W. Plaque biofilm penetration by essential-oil and CPC containing mouthrinses. Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. Abstract 0285. 9.Ricci-Nittel, Fourre T. Evaluation of antimicrobial mouthrinses using a microplate-based flow-through biofilm model. Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. Abstract 0287. 10.Witt JJ, Isaacs RL, Mau M, et al. Efficacy of two experimental CPC mouthrinses in a 6-month study. Presented at: 83rd General Session of the International Association for Dental Research; March 9-12, 2005; Baltimore, MD. Abstract 3598. 11.Peridex™ (0.12% chlorhexidine gluconate) Oral Rinse [prescribing information]. St Paul, MN: 3M ESPE Dental Products; 2008. 12.Overholser CD, Meiller TF, DePaola LG, et al. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17(8):575-579. 13.Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135(4):496-504.
