• Only OTC mouthwash proven as effective as a prescription rinse containing Chlorhexidine (CHX) and is safe for everyday use ^1-3**
• 3x greater bacteria-killing power than CREST Pro-Health ^1**
• Powerful, broad spectrum germ-killing action of the 4 ESSENTIAL Oils with alcohol is delivered throughout the mouth and deep into biofilm ^4**
• Only nationally branded OTC antimicrobial mouthwash with the ADA Seal of Acceptance

How does LISTERINE^® Antiseptic penetrate and kill plaque biofilm?

Our unique formula includes 4 ESSENTIAL Oils—eucalyptol, menthol, methyl salicylate, and thymol. Alcohol solubilizes and dissolves the oils to allow them to more deeply penetrate biofilm thoughout the mouth.

The superior anti-microbial action of our formula:^1,4

• DESTROYS the bacterial cell surface
• INHIBITS biofilm growth
• INCREASES the time bacteria takes to grow back

LISTERINE^® Antiseptic attacks and kills bacteria deep within the biofilm

Rinsing 30 seconds twice daily with 20 ml of
full-strength LISTERINE^® Antiseptic yields greater bacterial kill and greater plaque reduction

BEFORE
Scanning electron micrograph (SEM) of biofilm not treated with LISTERINE^® Antiseptic

AFTER
SEM of biofilm treated with LISTERINE^® Antiseptic

CLOSE UP
SEM of ruptured bacterial cell wall in LISTERINE^® Antiseptic-treated biofilm

Images courtesy of Christoph Schaudinn, PhD, University of Southern California School of Dentistry, Center for Biofilms.

How much deeper is the LISTERINE^® Antiseptic clean?

Study confirms the powerful biofilm kill of LISTERINE^® Antiseptic5

Powerful biofilm kill without the side effects^5-9

• Superior kill vs CPC-based rinses (0.05% to 0.07%) like CREST^® PRO–HEALTH^™, without the side effect of staining^5,10
• Comparable kill vs CHX-containing rinses (0.12%) like PERIDEX^™, without the side effects of staining and altered taste¹¹

How does LISTERINE^® Antiseptic help your patients achieve an overall healthier mouth?

In a long-term clinical study,
LISTERINE^® Antiseptic showed comparable reduction of gingivitis at 6 months vs PERIDEX™³

STUDY DESIGN⁵

• In this lab model, saliva-derived biofilms were grown on saliva-coated glass slides
• Biofilms were cultured for 65 hours prior to mouthrinse exposure
• Biofilms were stained to enable quantification of the live/dead cells

Powerful biofilm kill without the side effects^5-9

• Superior kill vs CPC-based rinses (0.05% to 0.07%) like CREST^® PRO–HEALTH^™, without the side effect of staining^5,10

LISTERINE^® Antiseptic, when added to brushing and flossing, reduces significantly more plaque and gingivitis vs brushing and flossing alone⁴

• 52% greater plaque reduction at 6 months when added to brushing and flossing⁴
• 21% greater gingivitis reduction vs brushing and flossing⁴
• In a separate study, up to 70% greater plaque reduction was demonstrated with LISTERINE^® Antiseptic vs brushing alone⁵

The ADA Council on Scientific Affairs' Acceptance of LISTERINE® Antiseptic is based on its finding that the product is effective in helping to prevent or reduce gingivitis and plaque above the gumline, when used as directed.^††

REFERENCES:

1. Pan PC, Harper S, Ricci-Nittel D, Lux R, Shi W. In-vitro evidence for efficacy of animicrobial mouthrinses. Journal of Dentistry. 2010;38(1):16-20. 2. Charles CH, Mostler KM, Bartels LL, Mankodi SM. Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. J Clin Periodontol 2004;31(10):878-884. 3. Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol 1990;17(8):575-579. 4. Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135(4):496-504. 5. Data on file, McNEIL-PPC, Inc. 6. Lux R, Pan SD, Castaneda JH, et al. Biocidal activity of antiseptic mouthrinses in saliva-derived biofilm model. Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. Abstract 1339. 7. Pan P, Lux R, Shi W, et al. Evaluation of plaque biofilm kill activity of representative global mouthrinses. Presented at: American Association for Dental Research Annual Meeting; April 2-5, 2008; Dallas, TX. Abstract 0031. 8. Araujo MWB, Pan P, Lux R, Shi W. Plaque biofilm penetration by essential-oil and CPC containing mouthrinses. Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. Abstract 0285. 9. Ricci-Nittel, Fourre T. Evaluation of antimicrobial mouthrinses using a microplate-based flow-through biofilm model. Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. Abstract 0287. 10. Witt JJ, Isaacs RL, Mau M, et al. Efficacy of two experimental CPC mouthrinses in a 6-month study. Presented at: 83rd General Session of the International Association for Dental Research; March 9-12, 2005; Baltimore, MD. Abstract 3598. 11. Peridex™ (0.12% chlorhexidine gluconate) Oral Rinse [prescribing information]. St Paul, MN: 3M ESPE Dental Products; 2008.