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Deepest Clean Study: LISTERINE® Antiseptic Rinse

How can this essential rinse extend your deep clean?*

  • As effective as other prescription rinses containing Chlorhexidine1-3†
  • Powerful, broad spectrum germ-killing action of the 4 Essential Oils with alcohol is delivered throughout the mouth and deep into biofilm1,4,5


LISTERINE® Antiseptic cleans where brushing can't.

This effective rinse kills germs in virtually 100% of the mouth, penetrating to kill plaque biofilm.1,4,5,7

LISTERINE® Antiseptic Chart

How does a little time go a long way?

Rinsing 30 seconds, twice daily, with 20 ml of full-strength LISTERINE® Antiseptic yields greater bacterial kill and greater plaque reduction.

Stain Chart

How much deeper is the LISTERINE® Antiseptic clean?

Superior biofilm kill power vs other products§

Peridex Bio-Film Chart

How does LISTERINE® Antiseptic help your patients achieve an overall healthier mouth?

Significant reduction of gingivitis at 6 months§

Peridex Gingivitis Chart

Count on powerful biofilm kill without the side effects8,10-15

Superior kill vs CPC-based rinses (0.05% to 0.07%) like Crest® Pro–Health, without the side effect of staining1,16

When added to brushing and flossing, LISTERINE® Antiseptic significantly reduces more plaque and gingivitis vs brushing and flossing alone4

Studies show...

Plaque and Gingivits Reduction

Greater Plaque Reduction

Want to know more?

To learn more about why the BRUSH, FLOSS & RINSE® routine is so crucial, check out our Journal Library and Guidelines for At-Home Care.


The ADA Council on Scientific Affairs' Acceptance of LISTERINE® Antiseptic is based on its finding that the product is effective in helping to prevent or reduce gingivitis and plaque above the gumline, when used as directed.||

* Rinsing with LISTERINE® Antiseptic does not replace a routine professional prophylaxis and is not indicated for the treatment of periodontitis or tartar removal.
§ STUDY DESIGN: In this lab model, saliva-derived biofilms were grown on saliva-coated glass slides Biofilms were cultured for 65 hours prior to mouthrinse exposure. Biofilms were stained to enable quantification of the live/dead cells.
||ADVANCED LISTERINE® (Citrus or ARCTIC MINT®) does not carry the ADA Seal of Acceptance.

REFERENCES: 1. Pan PC, Harper S, Ricci-Nittel D, Lux R, Shi W. In-vitro evidence for efficacy of antimicrobial mouthrinses. J Dent. 2010;38(suppl 1):S16-S20. 2. Charles CH, Mostler KM, Bartels LL, Mankodi SM. Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. J Clin Periodontol. 2004;31(10):878-884. 3. Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17(8):575-579. 4. Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135(4):496-504. 5. Fine DH, Furgang D, Lieb R, Korik I, Vincent JW, Barnett ML. Effects of sublethal exposure to an antiseptic mouthrinse representative plaque bacteria. J Clin Periodontol. 1996;23(S):444-451. 6. Oral health topics. ADA seal of product category. American Dental Association Web site. http://www.ada.org/5266.aspx?category= Plaque%2f Gingivitis+Control+Mouthrinse. Accessed March 16, 2012. 7. Ricci-Nittel D, Fourre T. In vivo evaluation of antimicrobial activity of an essential-oil mouthrinse. Presented at: General Session of the International Association for Dental Research; March 16-19, 2011; San Diego, CA. Oral Session. 8. DePaola LG. Safety and efficacy of antimicrobial mouthrinses in clinical practice. J Dent Hygiene. 2007 (special suppl);13:13-25. 9. Silverman S, Wilder R. Antimicrobial mouthrinse as part of a comprehensive oral care regimen: safety and compliance factors. J Am Dent Assoc. 2006;137(3):22S-26S. 10. Charles CH, Sharma NC, Galustians HJ, Qaqish J, McGuire JA, Vincent JW. Comparative efficacy of an antiseptic mouthrinse and an antiplaque/ antigingivitis dentifrice: a six-month clinical trial. J Am Dent Assoc. 2001;132(5): 670-675. 11. van Leeuwen MP, Slot DE, Van der Wijden GA. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol. 2011;82(2):174-194. 12. Ross NM, Charles CH, Dills SS. Long-term effects of Listerine Antiseptic on dental plaque and gingivitis. J Clin Dent. 1989:1(4):92-95. 13. Peridex®[prescribing information]. St Paul, MN: 3M ESPE Dental Products; 2008. 14. Lamster IB, Alfano MC, Seiger MC, Gordon JM. The effect of Listerine antiseptic on reduction of existing plaque and gingivitis. Clin Prev Dent. 1983;5(6):12-16. 15. Gordon JM, Lamster IB, Seiger MC. Efficacy of Listerine antiseptic in inhibiting the development of plaque and gingivitis. J Clin Periodontol. 1985;(12):697-704. 16. Ricci-Nittel D, Fourre T. Evaluation of antimicrobial mouthrinses using a microplate-based flow-through biofilm model (abstract). Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. 17. Lisante TA, Charles C, Qaqish J, Sharma N, Junker L. Efficacy of brush, floss, rinse regiments vs mechanical oral hygiene. Presented at: 86th General Session of the International Association for Dental Research; March 16-19, 2011; San Diego CA. Poster Session. 18. Data on file, McNEIL-PPC, Inc.