LISTERINE® Antiseptic cleans where brushing can't.
This effective rinse kills germs in virtually 100% of the mouth, penetrating to kill plaque biofilm.1,4,5,7
How does a little time go a long way?
Rinsing 30 seconds, twice daily, with 20 ml of full-strength LISTERINE® Antiseptic yields greater bacterial kill and greater plaque reduction.
How much deeper is the LISTERINE® Antiseptic clean?
Superior biofilm kill power vs other products§
How does LISTERINE® Antiseptic help your patients achieve an overall healthier mouth?
Significant reduction of gingivitis at 6 months§
Count on powerful biofilm kill without the side effects8,10-15
Superior kill vs CPC-based rinses (0.05% to 0.07%) like Crest® Pro–Health, without the side effect of staining1,16
When added to brushing and flossing, LISTERINE® Antiseptic significantly reduces more plaque and gingivitis vs brushing and flossing alone4
Want to know more?
The ADA Council on Scientific Affairs' Acceptance of LISTERINE® Antiseptic is based on its finding that the product is effective in helping to prevent or reduce gingivitis and plaque above the gumline, when used as directed.||
* Rinsing with LISTERINE® Antiseptic does not replace a routine professional prophylaxis and is not indicated for the treatment of periodontitis or tartar removal.
The mode of action of LISTERINE® Antiseptic has been shown to penetrate biofilms significantly (1 x 60 seconds) and when used as per recommended directions (2 x 30 seconds) % reduction can be as much as 3x greater than CPH.
vs Crest® Pro-Health Rinse in vitro.
§ STUDY DESIGN: In this lab model, saliva-derived biofilms were grown on saliva-coated glass slides Biofilms were cultured for 65 hours prior to mouthrinse exposure. Biofilms were stained to enable quantification of the live/dead cells.
||ADVANCED LISTERINE® (Citrus or ARCTIC MINT®) does not carry the ADA Seal of Acceptance.
REFERENCES: 1. Pan PC, Harper S, Ricci-Nittel D, Lux R, Shi W. In-vitro evidence for efficacy of antimicrobial mouthrinses. J Dent. 2010;38(suppl 1):S16-S20. 2. Charles CH, Mostler KM, Bartels LL, Mankodi SM. Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. J Clin Periodontol. 2004;31(10):878-884. 3. Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17(8):575-579. 4. Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135(4):496-504. 5. Fine DH, Furgang D, Lieb R, Korik I, Vincent JW, Barnett ML. Effects of sublethal exposure to an antiseptic mouthrinse representative plaque bacteria. J Clin Periodontol. 1996;23(S):444-451. 6. Oral health topics. ADA seal of product category. American Dental Association Web site. http://www.ada.org/5266.aspx?category= Plaque%2f Gingivitis+Control+Mouthrinse. Accessed March 16, 2012. 7. Ricci-Nittel D, Fourre T. In vivo evaluation of antimicrobial activity of an essential-oil mouthrinse. Presented at: General Session of the International Association for Dental Research; March 16-19, 2011; San Diego, CA. Oral Session. 8. DePaola LG. Safety and efficacy of antimicrobial mouthrinses in clinical practice. J Dent Hygiene. 2007 (special suppl);13:13-25. 9. Silverman S, Wilder R. Antimicrobial mouthrinse as part of a comprehensive oral care regimen: safety and compliance factors. J Am Dent Assoc. 2006;137(3):22S-26S. 10. Charles CH, Sharma NC, Galustians HJ, Qaqish J, McGuire JA, Vincent JW. Comparative efficacy of an antiseptic mouthrinse and an antiplaque/ antigingivitis dentifrice: a six-month clinical trial. J Am Dent Assoc. 2001;132(5): 670-675. 11. van Leeuwen MP, Slot DE, Van der Wijden GA. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol. 2011;82(2):174-194. 12. Ross NM, Charles CH, Dills SS. Long-term effects of Listerine Antiseptic on dental plaque and gingivitis. J Clin Dent. 1989:1(4):92-95. 13. Peridex®[prescribing information]. St Paul, MN: 3M ESPE Dental Products; 2008. 14. Lamster IB, Alfano MC, Seiger MC, Gordon JM. The effect of Listerine antiseptic on reduction of existing plaque and gingivitis. Clin Prev Dent. 1983;5(6):12-16. 15. Gordon JM, Lamster IB, Seiger MC. Efficacy of Listerine antiseptic in inhibiting the development of plaque and gingivitis. J Clin Periodontol. 1985;(12):697-704. 16. Ricci-Nittel D, Fourre T. Evaluation of antimicrobial mouthrinses using a microplate-based flow-through biofilm model (abstract). Presented at: 86th General Session of the International Association for Dental Research; July 2-5, 2008; Toronto, Canada. 17. Lisante TA, Charles C, Qaqish J, Sharma N, Junker L. Efficacy of brush, floss, rinse regiments vs mechanical oral hygiene. Presented at: 86th General Session of the International Association for Dental Research; March 16-19, 2011; San Diego CA. Poster Session. 18. Data on file, McNEIL-PPC, Inc.