Data with Unmatched Depth

The Data Don't Lie…

Patients who brush and floss, or just brush, can expect significantly improved gingival health when LISTERINE^® Antiseptic is added and used daily.

Even for those who brush and floss, the addition of LISTERINE^® Antiseptic provides 52% greater plaque reduction and 21% greater gingivitis reduction (study based on a home-use test among subjects with mild-to-moderate gingivitis).²

…Germs Will Die

• 24-hour protection against plaque and gingivitis germs when used every 12 hours^3,4
• LISTERINE^® Antiseptic is the only branded over-the-counter mouthrinse proven to rapidly kill–within 30 seconds of exposure–a broad spectrum of bacteria, 20 distinct species for oral health5-7
• Also proven to kill 7 essential species of microorganisms that lead to plaque and gingivitis5-7
• The germ-killing power of LISTERINE^® Antiseptic was unaffected by the presence or absence of serum4,7,10
• Adjunctive use of LISTERINE^® Antiseptic has been proven in multiple long-term clinical studies to significantly inhibit supragingival plaque by up to 56% and gingivitis by up to 36%–even in hard-to-reach areas

50 x 30

The efficacy of LISTERINE^® Antiseptic in improving oral health has been rigorously studied over the last 50 years in more than 30 published clinical studies (not to mention 100 years of safe use).

LISTERINE^® Antiseptic Penetrates Plaque Biofilm

• Does not affect the balance of oral flora8,9
• No increase in opportunistic pathogens or resistant strains8,9
• Proven to work on the teeth, between the teeth, and along the gumline10-13
• Efficacy statements apply to LISTERINE^® Antiseptic Mouthrinses only and do not apply to other LISTERINE^® Antiseptic Products
• Review the full articles on biofilm penetration

Healthier Mouth, Healthy Body

Over 50% of the U.S. adult population has some form of gingivitis.1 The average time spent brushing is less than one minute,14 and 79% of patients do not floss adequately.15 Clearly, mechanical plaque removal at home isn't always enough. And to make matters even worse, poor oral health may increase the risk for broader health problems:

• Emerging science suggests a link between advanced gum disease and the overall health of the body (the early stage of gum disease is gingivitis)
• Although no causal link has been established, one theory suggests that over time, advanced gum disease can contribute to broader health problems
• LISTERINE^® Antiseptic is not indicated for advanced gum disease

Proper brushing twice a day and flossing once a day should be a part of every patient's routine. Adding LISTERINE^® Antiseptic daily to a routine of brushing and flossing is clinically proven to reduce significantly more plaque and gingivitis. And, rinsing with LISTERINE^® Antiseptic in the morning and evening (every 12 hours) can give your patients' 24-hour, whole-mouth protection against plaque and gingivitis germs. LISTERINE^® Antiseptic is indicated to help prevent and reduce plaque and gingivitis.

Learn more about LISTERINE^® Antiseptic:

• Safety
• Ingredient Comparison

REFERENCES:

1.Oliver RC, Brown LJ, Loe H. Periodontal diseases in the United States population. J Periodontol. 1998;69:269-278. 2.Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135:496-504. 3.Furgang D, Sinatra K, Schreiner H, Charles C, Peng P, Fine D. In vivo antimicrobial activity of an essential oil mouthrinse. The IADR/AADR/CADR 80th General Session (March 6-9, 2002), San Diego, CA. Abstract 2854. 4.Fine DH, Furgang D, Sinatra K, Charles C, McGuire A, Kumar LD. In vivo antimicrobial effectiveness of an essential oil-containing mouth rinse 12 h after a single use and 14 days' use. J Clin Periodontol. 2005;32:335-340. 5.Pan P, Barnett ML, Coelho J, Brogdon C, Finnegan MB. Determination of the in situ bactericidal activity of an essential oil mouthrinse using a vital stain method. J Clin Periodontol. 2000;27:256-261. 6.Data on file, McNEIL-PPC, Inc. 7.Ross NM, Charles CH, Dills SS. Long-term effects of LISTERINE® Antiseptic on dental plaque and gingivitis. J Clin Dent. 1989;1:92-95. 8.Walker C, Clark W, Wheeler T, Lamm R. Evaluation of microbial shifts in supragingival plaque following long-term use of an oral antiseptic mouthrinse (abstract). J Dent Res. 1989;68:412. 9.Minah GE, DePaola LG, Overholser CD, et al. Effects of 6 months use of an antiseptic mouthrinse on supragingival dental plaque microflora. J Clin Periodontol. 1989;16:347-352. 10.Fine DH, Furgang D, Barnett ML, et al. Effect of an essential oil-containing antiseptic mouthrinse on plaque and salivary Streptococcus mutans levels. J Clin Periodontol. 2000;27:157-161. 11.Charles CH, Pan PC, Sturdivant L, Vincent JW. In vivo antimicrobial activity of an essential oil-containing mouthrinse on interproximal plaque bacteria. J Clin Dent. 2000;11:94-97. 12.Furgang D, Markowitz K, Goldsmith D, Charles C, Lynch M, Fine D. Antimicrobial mouthrinse reduces subgingival plaque organisims after two weeks use. The IADR/AADR/CADR 83 Rd General Session (March 9-12, 2005), Baltimore, MD. Abstract 2596. 13.Pianotti R, Pitts G. Effects of an antiseptic mouthwash on odorigenic microbes in the human gingival crevice. J Dent Res. 1978;57(2):175-179. 14.Emling RC, Flickinger KC, Cohen DW, Yankell SL. A comparison of estimated versus actual brushing time. Pharm and Ther in Dent. 1981;6:93-98. 15.Lang WP, et al. The relation of preventive dental behaviors to periodontal health status. J Clin Periodontol. 1989;21:194-198.