Overholser CD et al (1990)

COMPARATIVE EFFECTS OF 2 CHEMOTHERAPEUTIC MOUTHRINSES ON THE DEVELOPMENT OF SUPRAGINGIVAL DENTAL PLAQUE AND GINGIVITIS¹

Objective

To determine the efficacy and safety of LISTERINE^® Antiseptic and Peridex in helping to control supragingival plaque and gingivitis when used as an adjunct to normal oral hygiene routine and regular professional care.

Methods

This was a 6-month, randomized, double-blind, supervised, controlled clinical study in which 124 adult subjects received a professional dental prophylaxis and then rinsed for 30 seconds twice a day for 6 months with 20 mL of either LISTERINE^® Antiseptic, Peridex, or a 5% hydroalcohol control rinse in addition to their normal oral routine. Subjects were provided with a soft nylon toothbrush and fluoride toothpaste and were asked not to use any other mouthrinses during the study. At baseline and at 3 and 6 months, subjects were evaluated for gingivitis, supragingival plaque, extrinsic tooth stain, and supragingival calculus formation.

Results

At 6 months, LISTERINE^® Antiseptic produced a 36.1% inhibition of supragingival plaque development and a 35.9% inhibition of gingivitis development compared with the control group. Peridex provided a 50.3% reduction for plaque and 30.5% reduction for gingivitis compared to the control. There were no significant increases in either extrinsic tooth stain or supragingival calculus compared to baseline scores in either the LISTERINE^® Antiseptic or the control group.

LISTERINE^® Antiseptic Results